curcumenol

Botanical Classification of the Plant Source:

• Family: Zingiberaceae (Ginger Family)
• Genus: Curcuma
• Species: Phaeocaulis, Zedoari, Aeruginosa.
• Scientific Names:
  • Curcuma Phaeocaulis Valeton.
  • Curcuma Zedoaria (Christm.) Roscoe.
  • Curcuma Aeruginosa Roxb.

Distribution:

• South Asia: India, Bangla Desh
• Southeast Asia: Indonesia, Malaysia
• China.

Properties of Curcumenol:

• anti-inflammatory;
• inhibits cox-2;
• analgesic: being several times more potent than different reference medicines.

Scientific Data on Curcumenol:

• Synonyms: 6H-3a,6-Epoxyazulen-6-ol, 1,2,3,4,5,8a-hexahydro-3,8-dimethyl-5-(1-methylethylidene)-;
• Chemical formula: C15H22O2
• Molecular Weight: 234.34 g/mol
• Oil of C. Aeruginosa contains 9.4% Curcumenol.
• Extraction of Curcumenol: air-dried rhizomes > powdered > extracted twice with dichioromethane > ...
  Source: Phytomedicine. 2002 Jul;9(5):427-32.
  Title: Phytochemical analysis and analgesic properties of Curcuma zedoaria grown in Brazil.
  Author: Navarro Dde F, de Souza MM, Neto RA, Golin V, Niero R, Yunes RA, Delle Monache F, Cechinel Filho V.

The Plant: C. Phaeocaulis

• grows to 1m tall;
• leaves: oblong-lanceolate; dark brown with purple cloud at center;
• flowers: inflorescences;
• rhizomes: the source of curcumenol.

Historical Uses of C. Phaeocaulis:

Quotations from Research Articles on Curcumenol

Article 1. "... In addition, furanodienone and curcumenol were identified as the major active anti-inflammatory constituents of C. phaeocaulis, through detailed analysis of the regression vector, followed by isolation of these compounds and their COX-2 inhibitory assays. The selectivity indices (SI), IC(50) of COX-1/IC(50) of COX-2, of both compounds were higher than that of indomethacin and it is considered that furanodienone and curcumenol are the most promising compounds as lead anti-inflammatory agents."

Source: Chem Pharm Bull (Tokyo). 2008 Jul;56(7):936-40.
Title: Prediction of cyclooxygenase inhibitory activity of curcuma rhizome from chromatograms by multivariate analysis.
Author: Tanaka K, Kuba Y, Ina A, Watanabe H, Komatsu K. Division of Pharmacognosy, Department of Medicinal Resources, Institute of Natural Medicine, University of Toyama, Toyama, Japan.

Article 2. "... a pure compound, denoted as curcumenol (1), exhibited potent and dose-related analgesic activity when evaluated in several models of pain in mice, including writhing, formalin and capsaicin. Compound (1), which seems to be the main active principle from this plant, presented promising analgesic effects, being several times more potent than different reference (medicines) evaluated in the same experimental models. ... The results confirm and justify the popular use of this plant for the treatment of dolorous processes.

Source: Phytomedicine. 2002 Jul;9(5):427-32.
Title: Phytochemical analysis and analgesic properties of Curcuma zedoaria grown in Brazil.
Author: Navarro Dde F, de Souza MM, Neto RA, Golin V, Niero R, Yunes RA, Delle Monache F, Cechinel Filho V. Departamento de Farmácia, Universidade Estadual de Ponta Grossa, PR, Brazil.