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Article 1.
"... In addition, furanodienone and curcumenol were identified as the major active anti-inflammatory constituents of C. phaeocaulis, through detailed analysis of the regression vector, followed by isolation of these compounds and their COX-2 inhibitory assays. The selectivity indices (SI), IC(50) of COX-1/IC(50) of COX-2, of both compounds were higher than that of indomethacin and it is considered that furanodienone and curcumenol are the most promising compounds as lead anti-inflammatory agents."
Source: Chem Pharm Bull (Tokyo). 2008 Jul;56(7):936-40.
Title: Prediction of cyclooxygenase inhibitory activity of curcuma rhizome from chromatograms by multivariate analysis.
Author: Tanaka K, Kuba Y, Ina A, Watanabe H, Komatsu K. Division of Pharmacognosy, Department of Medicinal Resources, Institute of Natural Medicine, University of Toyama, Toyama, Japan.
Article 2.
"... a pure compound, denoted as curcumenol (1), exhibited potent and dose-related analgesic activity when evaluated in several models of pain in mice, including writhing, formalin and capsaicin. Compound (1), which seems to be the main active principle from this plant, presented promising analgesic effects, being several times more potent than different reference (medicines) evaluated in the same experimental models. ... The results confirm and justify the popular use of this plant for the treatment of dolorous processes.
Source: Phytomedicine. 2002 Jul;9(5):427-32.
Title: Phytochemical analysis and analgesic properties of Curcuma zedoaria grown in Brazil.
Author: Navarro Dde F, de Souza MM, Neto RA, Golin V, Niero R, Yunes RA, Delle Monache F, Cechinel Filho V.
Departamento de Farmácia, Universidade Estadual de Ponta Grossa, PR, Brazil.
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