Curcumenol

Curcumenol is a sesquiterpene phytochemical obtained from several plants of the type: Curcuma. It is currently being studied for its effects on arthritis.

Botanical Classification of the Plant Sources:

  • Family: Zingiberaceae (Ginger Family)
  • Genus: Curcuma
  • Species: Phaeocaulis, Zedoaria, Aeruginosa.

Distribution:

  • South Asia: India, Bangla Desh
  • Southeast Asia: Indonesia, Malaysia
  • China.

Properties of Curcumenol:

  • anti-inflammatory;
  • inhibits cox-2;
  • analgesic: being several times more potent than different reference medicines.
(Note: evidence is from laboratory and animal studies)

Scientific Data on Curcumenol:

  • Synonyms: 6H-3a,6-Epoxyazulen-6-ol, 1,2,3,4,5,8a-hexahydro-3,8-dimethyl-5-(1-methylethylidene)-;
  • Chemical formula: C15H22O2
  • Molecular Weight: 234.34 g/mol
  • Oil of C. Aeruginosa contains 9.4% Curcumenol.
  • To obtain Curcumenol: air-dried rhizomes > powdered > extracted twice with
    dichloromethane > ...
    Source: Phytomedicine. 2002 Jul;9(5):427-32.
    Title: Phytochemical analysis and analgesic properties of Curcuma zedoaria grown in Brazil.
    Author: Navarro Dde F, de Souza MM, Neto RA, Golin V, Niero R, Yunes RA, Delle Monache F, Cechinel Filho V.
curcumenol
Curcumenol
(Source: pubchem.ncbi.nlm.nih.gov)

The Plant: C. Phaeocaulis

  • grows to 1m tall;
  • leaves: oblong-lanceolate; dark brown with purple cloud at center;
  • flowers: inflorescences;
  • rhizomes: the source of curcumenol.

Genus: Curcuma
(Source: F. E. Kohler: Medizinal-Pflanzen, 1887)

Historical Uses of C. Phaeocaulis:

In traditional Chinese medicine, Ezhu and Jianghuang have been in customary use in China and Japan for centuries. These mixtures contain the rhizomes of C. Phaeocaulis, C. Kwangsiensis, C. Wenyujin and C. Longa.

Turmeric Extract, also known as Curcumin, from the plant Curcuma Longa may also be used for arthritis and is already available in the marketplace. Turmeric Extract profoundly inhibited joint inflammation and periarticular joint destruction in a dose-dependent manner in animal (non-human) experiments.

Quotations from Research Articles on Curcumenol

Article 1. "... In addition, furanodienone and curcumenol were identified as the major active anti-inflammatory constituents of C. phaeocaulis, through detailed analysis of the regression vector, followed by isolation of these compounds and their COX-2 inhibitory assays. The selectivity indices (SI), IC(50) of COX-1/IC(50) of COX-2, of both compounds were higher than that of indomethacin and it is considered that furanodienone and curcumenol are the most promising compounds as lead anti-inflammatory agents."

Source: Chem Pharm Bull (Tokyo). 2008 Jul;56(7):936-40.
Title: Prediction of cyclooxygenase inhibitory activity of curcuma rhizome from chromatograms by multivariate analysis.
Author: Tanaka K, Kuba Y, Ina A, Watanabe H, Komatsu K. Division of Pharmacognosy, Department of Medicinal Resources, Institute of Natural Medicine, University of Toyama, Toyama, Japan.

Article 2. "... a pure compound, denoted as curcumenol (1), exhibited potent and dose-related analgesic activity when evaluated in several models of pain in mice, including writhing, formalin and capsaicin. Compound (1), which seems to be the main active principle from this plant, presented promising analgesic effects, being several times more potent than different reference (medicines) evaluated in the same experimental models. ... The results confirm and justify the popular use of this plant for the treatment of dolorous processes.

Source: Phytomedicine. 2002 Jul;9(5):427-32.
Title: Phytochemical analysis and analgesic properties of Curcuma zedoaria grown in Brazil.
Author: Navarro Dde F, de Souza MM, Neto RA, Golin V, Niero R, Yunes RA, Delle Monache F, Cechinel Filho V. Departamento de Farmácia, Universidade Estadual de Ponta Grossa, PR, Brazil.


Old Herbs - New Science

Ananain and Comosain (from Pineapple stem)

Cinnamon Extract

Curcuma Longa

Curcumenol

Ficain (from Fig Trees)

Licorice Root Extract

Petty Spurge and Euphorbia Peplus

Rosmarinic Acid (from Rosemary, Sage)

Spanish Sage

Turmeric Extract

Vineatrol (from Grapevine shoots)

Withania Somnifera (Ashwagandha)

Withanolide (from Ashwagandha)

Zerumbone (from Ginger)
This website acknowledges Pubmed (www.ncbi.nlm.nih.gov) as source for medical research abstracts.

These statements have not been evaluated by the FDA. These products are not intended to diagnose, treat, cure, or prevent any disease. Pregnant or lactating women, diabetics, hypoglycemics, and people with known medical conditions and/or taking medicines should consult with a licensed physician and/or pharmacist prior to taking dietary supplements.
Contact Privacy Policy